مجله‌ي بین المللی غدد درون‌ريز و متابوليسمInt J Endocrinol MetabMedical Scienceshttp://www.ijem.org1726-913XenTraumatic Injury to the Brain and Endocrine Evaluation of the Anterior Pituitary a Year After the Event (The TRIBE Study)Robles JF^a, Navarro JEV^b, Maglinao MLD^b, Matawaran BJ^a, Andag-Silva AA^a, Mercado-Asis L B^aRobles JF^a Navarro JEV<sup>b</sup> Maglinao MLD<sup>b</sup> Matawaran BJ<sup>a</sup> Andag-Silva AA<sup>a</sup> Mercado-Asis L B<sup>a</sup><sup>a</sup>Departments of Endocrinology and Metabolism, <sup>b</sup>Department of Neurosurgery, University of Santo Tomas Hospital, Malina, PhilipineOriginal ArticleRecent clinical studies have shown that moderate and severe traumatic brain injury (TBI) is a common cause of hypopituitarism. Mild TBI has also been associated with hypopituitarism, which since it is often not evaluated, the hypopituitar-ism may remain under diagnosed. In this study we aimed at determining the clinical and hor-monal profile of mild TBI patients admitted a year after their injury. Materials &amp; Methods: The sample was a descrip-tive, prospective cohort in a tertiary hospital. A hypopituitarism clinical evaluation form was used to evaluate the patients for signs and symp-toms of hypopituitarism a year after mild TBI. Pituitary hormonal function was tested a year af-ter their injury for IGF-1, FT4, TSH, cortisol, LH, FSH and testosterone. Results: Six male patients with mild TBI were studied. Mean age was 27  8 years old. All of them had intra-cranial hemorrhage on CT-scan and five underwent emergency decompressive cranial surgery. Evaluation was done 481  67 days after the event. Signs of hypopituitarism were not observed but symptoms of decreased vigor and weight gain was present in five of the six patients. IGF-1 was low in 33% (2/6) and tes-tosterone level was low in 17% (1/6).8 am cortisol levels were equivocal in 83% (5/6) but ACTH-stimulated cortisol values were normal. Thyroid function test were normal for all subjects. Conclusion: The most common symptoms were weight gain &amp; decreased vigor. Signs of hypopi-tuitarism were not noted among the mild TBI pa-tients. Pituitary hormone testing revealed ab-normalities in the somatotrophic &amp; gonado-trophic axes.Traumatic brain injury, Hypopituitarism, Growth hormone deficiencyEndocrine impact of brain injuryL.B. Mercado. Asis5/9/2009 12:00:00 AM10/7/2009 12:00:00 AMleilanmimercadoosis@endo-society.org.ph277281http://www.ijem.org/Default.aspx