مجله‌ي بین المللی غدد درون‌ريز و متابوليسمInt J Endocrinol MetabMedical Scienceshttp://www.ijem.org1726-913XenExistence of Inhibin α-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian FailureFallahian M^a, Pouresmaeili F^b, Azizi F^c, Zali MR^d, Samani EM^a, Kharaziha P^dFallahian M^a Pouresmaeili F<sup>b</sup> Azizi F<sup>c</sup> Zali MR<sup>d</sup> Samani EM<sup>a</sup> Kharaziha P<sup>d</sup><sup>a</sup>Department of Obstetrics and Gynecology, <sup>b</sup>Department of Genetics, and Infertility &amp; Reproductive Health Research Center(IRHRC); <sup>c</sup>Endocrine Research Center, ResearOriginal ArticlePremature ovarian failure (POF) is characterized by hypergonadotropic amenorrhea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials &amp; Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran.Inhibin α-subunit gene, Premature ovarian failure, MutationInhibin α-subunit gene mutation Farkhondeh Pouresmaeili2/28/2009 12:00:00 AM7/15/2009 12:00:00 AMfpoures@yahoo.com276771http://www.ijem.org/Default.aspx